Assay Detail
Functional
CHEMBL5355529
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human beta1-adrenergic receptor expressed in CHO-K1 cells co-expressing CRE-SPAP reporter gene assessed as CRE-SPAP production measured after 5 hrs incubation
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Rational design, synthesis, and pharmacological evaluation of a cohort of novel beta-adrenergic receptors ligands enables an assessment of structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.91 | 7.96 |
| pEC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL32800 | FENOTEROL | 4.0 | 1 | 7.96 |
| CHEMBL1326499 | — | — | 1 | 7.32 |
| CHEMBL5427527 | — | — | 1 | 7.13 |
| CHEMBL5430355 | — | — | 1 | 6.52 |
| CHEMBL5397120 | — | — | 1 | 6.51 |
| CHEMBL5415148 | — | — | 1 | 6.50 |
| CHEMBL4238084 | — | — | 1 | 6.42 |
| CHEMBL5410388 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL32800 | FENOTEROL | EC50 | = | 10.96 | nM | 7.96 |
| CHEMBL1326499 | — | EC50 | = | 47.86 | nM | 7.32 |
| CHEMBL5427527 | — | EC50 | = | 74.13 | nM | 7.13 |
| CHEMBL5430355 | — | EC50 | = | 302.0 | nM | 6.52 |
| CHEMBL5397120 | — | EC50 | = | 309.03 | nM | 6.51 |
| CHEMBL5415148 | — | EC50 | = | 316.23 | nM | 6.50 |
| CHEMBL4238084 | — | EC50 | = | 380.19 | nM | 6.42 |
| CHEMBL5410388 | — | pEC50 | - | — | - |