Assay Detail
Functional
CHEMBL5355898
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Antiproliferative activity against human HCT-116 cells incubated for 72 hrs by CellTiter-Glo luminescent cell viability assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.12 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4550522 | — | — | 1 | 7.16 |
| CHEMBL3426804 | — | — | 1 | 7.16 |
| CHEMBL5401106 | — | — | 1 | 6.68 |
| CHEMBL5400896 | — | — | 1 | 6.58 |
| CHEMBL5409567 | — | — | 1 | 6.50 |
| CHEMBL5417858 | — | — | 1 | 6.37 |
| CHEMBL5419832 | — | — | 1 | 6.25 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.16 |
| CHEMBL5429873 | — | — | 1 | 6.06 |
| CHEMBL5411948 | — | — | 1 | 5.98 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.97 |
| CHEMBL5425559 | — | — | 1 | 5.88 |
| CHEMBL5418060 | — | — | 1 | 5.78 |
| CHEMBL5420814 | — | — | 1 | 5.56 |
| CHEMBL5414244 | — | — | 1 | 5.49 |
| CHEMBL5396691 | — | — | 1 | 5.36 |
| CHEMBL5409409 | — | — | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4550522 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3426804 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL5401106 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5400896 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5409567 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL5417858 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5419832 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5429873 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL5411948 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL5425559 | — | IC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL5418060 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL5420814 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL5414244 | — | IC50 | = | 3230.0 | nM | 5.49 |
| CHEMBL5396691 | — | IC50 | = | 4380.0 | nM | 5.36 |
| CHEMBL5409409 | — | IC50 | = | 8280.0 | nM | 5.08 |