Assay Detail
Functional
CHEMBL5356166
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV activity against wild type HIV-1 IIIB infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Development of novel S-N<sub>3</sub>-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 34 | 6.45 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.52 |
| CHEMBL5405590 | — | — | 1 | 7.28 |
| CHEMBL5422267 | — | — | 1 | 7.26 |
| CHEMBL5425978 | — | — | 1 | 7.17 |
| CHEMBL5434772 | — | — | 1 | 7.08 |
| CHEMBL5416641 | — | — | 1 | 6.85 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.80 |
| CHEMBL5411806 | — | — | 1 | 6.80 |
| CHEMBL5395674 | — | — | 1 | 6.66 |
| CHEMBL5400851 | — | — | 1 | 6.64 |
| CHEMBL5436998 | — | — | 1 | 6.58 |
| CHEMBL5414650 | — | — | 1 | 6.54 |
| CHEMBL5421659 | — | — | 1 | 6.54 |
| CHEMBL5439822 | — | — | 1 | 6.47 |
| CHEMBL5402260 | — | — | 1 | 6.47 |
| CHEMBL374286 | — | — | 1 | 6.43 |
| CHEMBL5419059 | — | — | 1 | 6.42 |
| CHEMBL5416663 | — | — | 1 | 6.42 |
| CHEMBL5404627 | — | — | 1 | 6.36 |
| CHEMBL5395659 | — | — | 1 | 6.33 |
| CHEMBL5415239 | — | — | 1 | 6.28 |
| CHEMBL5399408 | — | — | 1 | 6.28 |
| CHEMBL5428499 | — | — | 1 | 6.05 |
| CHEMBL5418380 | — | — | 1 | 6.04 |
| CHEMBL5419681 | — | — | 1 | 6.02 |
| CHEMBL5410784 | — | — | 1 | 5.94 |
| CHEMBL5434015 | — | — | 1 | 5.84 |
| CHEMBL5429802 | — | — | 1 | 5.75 |
| CHEMBL5411909 | — | — | 1 | 5.31 |
| CHEMBL5427605 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5405590 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL5422267 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL5425978 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL5434772 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL5416641 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5411806 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5395674 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL5400851 | — | EC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5436998 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5414650 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5421659 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL5439822 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5402260 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL374286 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5416663 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5419059 | — | EC50 | = | 380.0 | nM | 6.42 |
| CHEMBL5404627 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5395659 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL5415239 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL5399408 | — | EC50 | = | 520.0 | nM | 6.28 |
| CHEMBL5428499 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5418380 | — | EC50 | = | 920.0 | nM | 6.04 |
| CHEMBL5419681 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL5410784 | — | EC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL5434015 | — | EC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL5429802 | — | EC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL5411909 | — | EC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL5427605 | — | EC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL5403032 | — | EC50 | > | 59180.0 | nM | - |
| CHEMBL5433611 | — | EC50 | > | 4780.0 | nM | - |
| CHEMBL5430980 | — | EC50 | > | 308260.0 | nM | - |
| CHEMBL5424413 | — | EC50 | > | 319280.0 | nM | - |