Assay Detail
Functional
CHEMBL5356169
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV activity against drug resistant HIV-1 harboring L100I mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Development of novel S-N<sub>3</sub>-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 5.62 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.92 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.43 |
| CHEMBL5411806 | — | — | 1 | 6.89 |
| CHEMBL5425978 | — | — | 1 | 6.01 |
| CHEMBL5405590 | — | — | 1 | 5.98 |
| CHEMBL5433611 | — | — | 1 | 5.97 |
| CHEMBL5434015 | — | — | 1 | 5.84 |
| CHEMBL5430980 | — | — | 1 | 5.69 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.59 |
| CHEMBL5439822 | — | — | 1 | 5.58 |
| CHEMBL5436998 | — | — | 1 | 5.43 |
| CHEMBL5402260 | — | — | 1 | 5.28 |
| CHEMBL5419681 | — | — | 1 | 5.04 |
| CHEMBL374286 | — | — | 1 | 4.99 |
| CHEMBL5429802 | — | — | 1 | 4.99 |
| CHEMBL5421659 | — | — | 1 | 4.99 |
| CHEMBL5422267 | — | — | 1 | 4.97 |
| CHEMBL5395674 | — | — | 1 | 4.96 |
| CHEMBL5404627 | — | — | 1 | 4.95 |
| CHEMBL5416641 | — | — | 1 | 4.91 |
| CHEMBL5427605 | — | — | 1 | 4.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL5411806 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5425978 | — | EC50 | = | 970.0 | nM | 6.01 |
| CHEMBL5405590 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL5433611 | — | EC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL5434015 | — | EC50 | = | 1440.0 | nM | 5.84 |
| CHEMBL5430980 | — | EC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL5439822 | — | EC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL5436998 | — | EC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL5402260 | — | EC50 | = | 5270.0 | nM | 5.28 |
| CHEMBL5419681 | — | EC50 | = | 9180.0 | nM | 5.04 |
| CHEMBL374286 | — | EC50 | = | 10350.0 | nM | 4.99 |
| CHEMBL5429802 | — | EC50 | = | 10230.0 | nM | 4.99 |
| CHEMBL5421659 | — | EC50 | = | 10360.0 | nM | 4.99 |
| CHEMBL5422267 | — | EC50 | = | 10620.0 | nM | 4.97 |
| CHEMBL5395674 | — | EC50 | = | 11020.0 | nM | 4.96 |
| CHEMBL5404627 | — | EC50 | = | 11290.0 | nM | 4.95 |
| CHEMBL5416641 | — | EC50 | = | 12180.0 | nM | 4.91 |
| CHEMBL5427605 | — | EC50 | = | 29470.0 | nM | 4.53 |