Assay Detail
Functional
CHEMBL5356170
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV activity against drug resistant HIV-1 harboring K103N mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Development of novel S-N<sub>3</sub>-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 5.16 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.62 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 7.03 |
| CHEMBL5405590 | — | — | 1 | 5.60 |
| CHEMBL5433611 | — | — | 1 | 5.48 |
| CHEMBL5411806 | — | — | 1 | 5.41 |
| CHEMBL5425978 | — | — | 1 | 5.32 |
| CHEMBL5416641 | — | — | 1 | 5.22 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 5.09 |
| CHEMBL5434015 | — | — | 1 | 5.09 |
| CHEMBL5436998 | — | — | 1 | 4.85 |
| CHEMBL5430980 | — | — | 1 | 4.68 |
| CHEMBL5427605 | — | — | 1 | 4.42 |
| CHEMBL5421659 | — | — | 1 | 4.29 |
| CHEMBL5395674 | — | — | 1 | 4.21 |
| CHEMBL374286 | — | — | 1 | 4.17 |
| CHEMBL5419681 | — | — | 1 | 4.14 |
| CHEMBL5422267 | — | — | 1 | - |
| CHEMBL5439822 | — | — | 1 | - |
| CHEMBL5429802 | — | — | 1 | - |
| CHEMBL5404627 | — | — | 1 | - |
| CHEMBL5402260 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL5405590 | — | EC50 | = | 2510.0 | nM | 5.60 |
| CHEMBL5433611 | — | EC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5411806 | — | EC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL5425978 | — | EC50 | = | 4820.0 | nM | 5.32 |
| CHEMBL5416641 | — | EC50 | = | 6030.0 | nM | 5.22 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL5434015 | — | EC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL5436998 | — | EC50 | = | 14260.0 | nM | 4.85 |
| CHEMBL5430980 | — | EC50 | = | 20860.0 | nM | 4.68 |
| CHEMBL5427605 | — | EC50 | = | 38220.0 | nM | 4.42 |
| CHEMBL5421659 | — | EC50 | = | 51180.0 | nM | 4.29 |
| CHEMBL5395674 | — | EC50 | = | 61100.0 | nM | 4.21 |
| CHEMBL374286 | — | EC50 | = | 68280.0 | nM | 4.17 |
| CHEMBL5419681 | — | EC50 | = | 71560.0 | nM | 4.14 |
| CHEMBL5422267 | — | EC50 | > | 387450.0 | nM | - |
| CHEMBL5439822 | — | EC50 | = | 107340.0 | nM | - |
| CHEMBL5429802 | — | EC50 | > | 139080.0 | nM | - |
| CHEMBL5404627 | — | EC50 | > | 153540.0 | nM | - |
| CHEMBL5402260 | — | EC50 | > | 342000.0 | nM | - |