Assay Detail
Functional
CHEMBL5356173
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV activity against drug resistant HIV-1 harboring E138K mutant infected in human MT4 cells assessed as inhibition of virus-induced cytopathic effect by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Development of novel S-N<sub>3</sub>-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 21 | 6.19 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.22 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.57 |
| CHEMBL5433611 | — | — | 1 | 7.05 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.72 |
| CHEMBL5427605 | — | — | 1 | 6.58 |
| CHEMBL5405590 | — | — | 1 | 6.58 |
| CHEMBL5430980 | — | — | 1 | 6.43 |
| CHEMBL5425978 | — | — | 1 | 6.39 |
| CHEMBL5411806 | — | — | 1 | 6.35 |
| CHEMBL5416641 | — | — | 1 | 6.26 |
| CHEMBL5436998 | — | — | 1 | 6.09 |
| CHEMBL374286 | — | — | 1 | 6.06 |
| CHEMBL5402260 | — | — | 1 | 5.86 |
| CHEMBL5439822 | — | — | 1 | 5.81 |
| CHEMBL5421659 | — | — | 1 | 5.73 |
| CHEMBL5422267 | — | — | 1 | 5.58 |
| CHEMBL5395674 | — | — | 1 | 5.44 |
| CHEMBL5434015 | — | — | 1 | 5.43 |
| CHEMBL5429802 | — | — | 1 | 5.34 |
| CHEMBL5404627 | — | — | 1 | 5.30 |
| CHEMBL5419681 | — | — | 1 | 5.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5433611 | — | EC50 | = | 90.0 | nM | 7.05 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5427605 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5405590 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5430980 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5425978 | — | EC50 | = | 410.0 | nM | 6.39 |
| CHEMBL5411806 | — | EC50 | = | 450.0 | nM | 6.35 |
| CHEMBL5416641 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5436998 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL374286 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL5402260 | — | EC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL5439822 | — | EC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL5421659 | — | EC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL5422267 | — | EC50 | = | 2660.0 | nM | 5.58 |
| CHEMBL5395674 | — | EC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL5434015 | — | EC50 | = | 3690.0 | nM | 5.43 |
| CHEMBL5429802 | — | EC50 | = | 4560.0 | nM | 5.34 |
| CHEMBL5404627 | — | EC50 | = | 5040.0 | nM | 5.30 |
| CHEMBL5419681 | — | EC50 | = | 7340.0 | nM | 5.13 |