Assay Detail
ADMET
CHEMBL5356176
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured after 10 mins in presence of NADPH
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Tissue | Liver |
| Subcellular | Microsome |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of novel S-N<sub>3</sub>-DABO derivatives as potent non-nucleoside reverse transcriptase inhibitors with improved potency and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.30 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16073 | PHENACETIN | 4.0 | 1 | 8.30 |
| CHEMBL5405590 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16073 | PHENACETIN | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5405590 | — | IC50 | > | 50000.0 | nM | - |