Assay Detail
Functional
CHEMBL5356227
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-29 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 method
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b]pyridazine derivatives as potent PI3K/mTOR dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.52 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5395998 | — | — | 1 | 7.05 |
| CHEMBL5422635 | — | — | 1 | 6.82 |
| CHEMBL5413309 | — | — | 1 | 6.47 |
| CHEMBL5400439 | — | — | 1 | 6.26 |
| CHEMBL5415865 | — | — | 1 | 6.10 |
| CHEMBL3218576 | COPANLISIB | 4.0 | 1 | 6.03 |
| CHEMBL5428411 | — | — | 1 | 6.03 |
| CHEMBL5417402 | — | — | 1 | 5.76 |
| CHEMBL5401801 | — | — | 1 | 5.26 |
| CHEMBL5407573 | — | — | 1 | 5.02 |
| CHEMBL5403717 | — | — | 1 | 5.02 |
| CHEMBL5421477 | — | — | 1 | 5.00 |
| CHEMBL5398514 | — | — | 1 | 4.98 |
| CHEMBL5405706 | — | — | 1 | 4.86 |
| CHEMBL5405623 | — | — | 1 | 4.72 |
| CHEMBL5429174 | — | — | 1 | 4.30 |
| CHEMBL5394535 | — | — | 1 | 4.19 |
| CHEMBL4213353 | — | — | 1 | - |
| CHEMBL5402186 | — | — | 1 | - |
| CHEMBL5431325 | — | — | 1 | - |
| CHEMBL5415726 | — | — | 1 | - |
| CHEMBL5409142 | — | — | 1 | - |
| CHEMBL5401298 | — | — | 1 | - |
| CHEMBL5440536 | — | — | 1 | - |
| CHEMBL5432324 | — | — | 1 | - |
| CHEMBL5431132 | — | — | 1 | - |
| CHEMBL5428160 | — | — | 1 | - |
| CHEMBL5418523 | — | — | 1 | - |
| CHEMBL1765463 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5395998 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5422635 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5413309 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5400439 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5415865 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL3218576 | COPANLISIB | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL5428411 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL5417402 | — | IC50 | = | 1740.0 | nM | 5.76 |
| CHEMBL5401801 | — | IC50 | = | 5540.0 | nM | 5.26 |
| CHEMBL5407573 | — | IC50 | = | 9470.0 | nM | 5.02 |
| CHEMBL5403717 | — | IC50 | = | 9550.0 | nM | 5.02 |
| CHEMBL5421477 | — | IC50 | = | 10030.0 | nM | 5.00 |
| CHEMBL5398514 | — | IC50 | = | 10420.0 | nM | 4.98 |
| CHEMBL5405706 | — | IC50 | = | 13730.0 | nM | 4.86 |
| CHEMBL5405623 | — | IC50 | = | 19220.0 | nM | 4.72 |
| CHEMBL5429174 | — | IC50 | = | 50450.0 | nM | 4.30 |
| CHEMBL5394535 | — | IC50 | = | 63920.0 | nM | 4.19 |
| CHEMBL4213353 | — | IC50 | - | — | - | |
| CHEMBL5402186 | — | IC50 | - | — | - | |
| CHEMBL5431325 | — | IC50 | - | — | - | |
| CHEMBL5415726 | — | IC50 | - | — | - | |
| CHEMBL5409142 | — | IC50 | - | — | - | |
| CHEMBL5401298 | — | IC50 | - | — | - | |
| CHEMBL5440536 | — | IC50 | - | — | - | |
| CHEMBL5432324 | — | IC50 | - | — | - | |
| CHEMBL5431132 | — | IC50 | - | — | - | |
| CHEMBL5428160 | — | IC50 | - | — | - | |
| CHEMBL5418523 | — | IC50 | - | — | - | |
| CHEMBL1765463 | — | IC50 | - | — | - |