Compound Detail
CHEMBL5432324
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL5432324 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZZADACQWOYYCBA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
513.6
MW (Da)
1.15
ALogP
12
HBA
1
HBD
141.7
PSA (Ų)
0.35
QED
2
Ro5 Violations
9
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 8.96 | 8.96 | 1.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 1.09 | nM | 8.96 | Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate incubated for 1... | 36586298 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 36586298 | 10.1016/j.ejmech.2022.115030 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 36586298 | 10.1016/j.ejmech.2022.115030 | HT-29 | 1 |
Data from ChEMBL 36 via Core Engine