Assay Detail
Binding
CHEMBL5356228
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PI3Kbeta (unknown origin) using PIP2 as substrate incubated for 1 hr in presence of ATP by ADP-Glo assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b]pyridazine derivatives as potent PI3K/mTOR dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.84 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4440406 | — | — | 1 | 9.24 |
| CHEMBL5395998 | — | — | 1 | 8.95 |
| CHEMBL3218576 | COPANLISIB | 4.0 | 1 | 8.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4440406 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL5395998 | — | IC50 | = | 1.13 | nM | 8.95 |
| CHEMBL3218576 | COPANLISIB | IC50 | = | 4.57 | nM | 8.34 |