Assay Detail
Functional
CHEMBL5356232
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth incubated for 72 hrs by CCK-8 method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b]pyridazine derivatives as potent PI3K/mTOR dual inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.77 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422635 | — | — | 1 | 7.16 |
| CHEMBL3218576 | COPANLISIB | 4.0 | 1 | 6.89 |
| CHEMBL5395998 | — | — | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422635 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL3218576 | COPANLISIB | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5395998 | — | IC50 | = | 540.0 | nM | 6.27 |