Assay Detail
Binding
CHEMBL5356275
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of TBK1 (unknown origin) incubated for 1 hr in presence of ATP by FRET based Z'-Lyte assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase TBK1 (CHEMBL5408) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.42 | 7.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5412271 | — | — | 1 | 7.65 |
| CHEMBL3605057 | — | — | 1 | 7.64 |
| CHEMBL5438323 | — | — | 1 | 7.45 |
| CHEMBL5412535 | — | — | 1 | 7.30 |
| CHEMBL5394835 | — | — | 1 | 7.27 |
| CHEMBL5401353 | — | — | 1 | 7.18 |
| CHEMBL5400647 | — | — | 1 | - |
| CHEMBL5431622 | — | — | 1 | - |
| CHEMBL5425152 | — | — | 1 | - |
| CHEMBL5395610 | — | — | 1 | - |
| CHEMBL5403014 | — | — | 1 | - |
| CHEMBL5437308 | — | — | 1 | - |
| CHEMBL5424720 | — | — | 1 | - |
| CHEMBL5411811 | — | — | 1 | - |
| CHEMBL5431220 | — | — | 1 | - |
| CHEMBL5399754 | — | — | 1 | - |
| CHEMBL5400015 | — | — | 1 | - |
| CHEMBL5419757 | — | — | 1 | - |
| CHEMBL5426526 | — | — | 1 | - |
| CHEMBL5423172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5412271 | — | IC50 | = | 22.4 | nM | 7.65 |
| CHEMBL3605057 | — | IC50 | = | 23.1 | nM | 7.64 |
| CHEMBL5438323 | — | IC50 | = | 35.7 | nM | 7.45 |
| CHEMBL5412535 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL5394835 | — | IC50 | = | 53.6 | nM | 7.27 |
| CHEMBL5401353 | — | IC50 | = | 66.7 | nM | 7.18 |
| CHEMBL5400647 | — | IC50 | - | — | - | |
| CHEMBL5431622 | — | IC50 | - | — | - | |
| CHEMBL5425152 | — | IC50 | - | — | - | |
| CHEMBL5395610 | — | IC50 | - | — | - | |
| CHEMBL5403014 | — | IC50 | - | — | - | |
| CHEMBL5437308 | — | IC50 | - | — | - | |
| CHEMBL5424720 | — | IC50 | - | — | - | |
| CHEMBL5411811 | — | IC50 | - | — | - | |
| CHEMBL5431220 | — | IC50 | - | — | - | |
| CHEMBL5399754 | — | IC50 | - | — | - | |
| CHEMBL5400015 | — | IC50 | - | — | - | |
| CHEMBL5419757 | — | IC50 | - | — | - | |
| CHEMBL5426526 | — | IC50 | - | — | - | |
| CHEMBL5423172 | — | IC50 | - | — | - |