Assay Detail
Functional
CHEMBL5356791
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Antiproliferative activity against human Hs746T cells assessed as inhibition of cell growth
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hs746T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting MET: Discovery of Small Molecule Inhibitors as Non-Small Cell Lung Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.80 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5428302 | — | — | 1 | 8.70 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | 8.00 |
| CHEMBL3039525 | GOLVATINIB | 2.0 | 1 | 7.64 |
| CHEMBL3984441 | NINGETINIB | 2.0 | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5428302 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL3039525 | GOLVATINIB | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3984441 | NINGETINIB | IC50 | = | 140.0 | nM | 6.85 |