Assay Detail
Binding
CHEMBL5357110
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Inhibition of bacterial NDM-1 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small-molecule inhibitors of bacterial-producing metallo-β-lactamases: insights into their resistance mechanisms and biochemical analyses of their activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.80 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5193687 | — | — | 1 | 7.02 |
| CHEMBL484853 | CARNOSIC ACID | — | 1 | 4.57 |
| CHEMBL5425717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5193687 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL484853 | CARNOSIC ACID | IC50 | = | 27070.0 | nM | 4.57 |
| CHEMBL5425717 | — | IC50 | = | 0.084 | ug.mL-1 | - |