Assay Detail
Binding
CHEMBL5357353
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Inhibition of haspin (unknown origin) assessed as dissociation constant
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase haspin (CHEMBL1075163) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Dual FLT3/haspin kinase inhibitor based on 3<i>H</i>-pyrazolo[4,3-<i>f</i>]quinoline scaffold with activities against acute myeloid leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 9.26 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5440655 | — | — | 1 | 9.26 |
| CHEMBL5178368 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5440655 | — | Kd | = | 0.55 | nM | 9.26 |
| CHEMBL5178368 | — | Kd | < | 0.17 | nM | - |