Assay Detail
Binding
CHEMBL5357380
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Protac activity at CRBN/CDK12 in human MOLT-4 cells assessed as reduction of protein degradation by Westernblot analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MOLT-4 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Protein cereblon/Cyclin-dependent kinase 12 (CHEMBL4879535) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Research progress of anticancer drugs targeting CDK12.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.51 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5424163 | — | — | 1 | 8.05 |
| CHEMBL4555799 | — | — | 1 | 6.97 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5424163 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4555799 | — | IC50 | = | 107.0 | nM | 6.97 |