Assay Detail
Binding
CHEMBL5357891
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Inhibition of pancreatic lipase (unknown origin) by spectrophotometeric analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation and molecular docking of alkoxyaurones as potent pancreatic lipase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.07 | 7.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175247 | ORLISTAT | 4.0 | 1 | 7.48 |
| CHEMBL5416736 | — | — | 1 | 5.71 |
| CHEMBL5425089 | — | — | 1 | 5.21 |
| CHEMBL5407888 | — | — | 1 | 5.04 |
| CHEMBL5404797 | — | — | 1 | 4.44 |
| CHEMBL5439698 | — | — | 1 | 4.42 |
| CHEMBL382905 | — | — | 1 | 4.23 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 4.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175247 | ORLISTAT | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL5416736 | — | IC50 | = | 1945.0 | nM | 5.71 |
| CHEMBL5425089 | — | IC50 | = | 6154.0 | nM | 5.21 |
| CHEMBL5407888 | — | IC50 | = | 9012.0 | nM | 5.04 |
| CHEMBL5404797 | — | IC50 | = | 36660.0 | nM | 4.44 |
| CHEMBL5439698 | — | IC50 | = | 37670.0 | nM | 4.42 |
| CHEMBL382905 | — | IC50 | = | 58770.0 | nM | 4.23 |
| CHEMBL50 | QUERCETIN | IC50 | = | 86980.0 | nM | 4.06 |