Assay Detail
Binding
CHEMBL5358934
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Staphylococcus aureus dihydrofolate reductase using dihydrofolate as substrate in presence of NADPH by microplate reader analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological and molecular modelling for 1,3,4-thiadiazole sulfonyl thioureas: bacterial and fungal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.52 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.72 |
| CHEMBL5422204 | — | — | 1 | 6.64 |
| CHEMBL5427814 | — | — | 1 | 6.46 |
| CHEMBL5419490 | — | — | 1 | 6.43 |
| CHEMBL5407144 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL5422204 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5427814 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5419490 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5407144 | — | IC50 | = | 470.0 | nM | 6.33 |