Assay Detail
Binding
CHEMBL5358950
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Inhibition of bacterial NDM-1
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aurones and derivatives as promising New Delhi metallo-β-lactamase (NDM-1) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.17 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5413366 | — | — | 1 | 7.96 |
| CHEMBL4584705 | — | — | 1 | 7.09 |
| CHEMBL5173546 | — | — | 1 | 5.39 |
| CHEMBL2005280 | — | — | 1 | 5.29 |
| CHEMBL434965 | D-CAPTOPRIL | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5413366 | — | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL4584705 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL5173546 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL2005280 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL434965 | D-CAPTOPRIL | Ki | = | 7900.0 | nM | 5.10 |