Assay Detail
Binding
CHEMBL5359218
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Inhibition of Plasmodium falciparum Threonyl tRNA synthetase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Malarial Threonyl tRNA Synthetase Inhibitors by Screening of a Focused Fragment Library.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.45 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL70590 | BORRELIDIN | — | 1 | 7.37 |
| CHEMBL2311925 | — | — | 1 | 7.24 |
| CHEMBL1163068 | — | — | 1 | 6.80 |
| CHEMBL5438745 | — | — | 1 | 6.36 |
| CHEMBL5400120 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL70590 | BORRELIDIN | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL2311925 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL1163068 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5438745 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL5400120 | — | IC50 | = | 33000.0 | nM | 4.48 |