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Assay Detail

CHEMBL5359451

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Acetogenins from the Stem of <i>Uvaria rufa</i> and Their Cytotoxic Activity.
Gurgul A, Khin M, Souliya O, Sydara K, Burdette JE, Johnson JJ, Che CT.
J Nat Prod (2024) 87 : 207 -216
PubMed 38237151 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.68 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL378544 VINBLASTINE SULFATE 4.0 1 9.00
CHEMBL5434987 1 5.92
CHEMBL41177 SQUAMOCIN 1 5.92
CHEMBL44657 ETOPOSIDE 4.0 1 5.75
CHEMBL5426008 1 5.75
CHEMBL5399730 1 5.57
CHEMBL62800 ISODESAACETYLUVARICIN 1 5.55
CHEMBL1933125 UVARIGRANDIN A 1 5.26
CHEMBL5410230 1 5.04
CHEMBL5405302 1 5.00
CHEMBL5431384 1 4.82
CHEMBL145449 BULLANIN 1 4.54

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL378544 VINBLASTINE SULFATE IC50 = 1.0 nM 9.00
CHEMBL5434987 IC50 = 1200.0 nM 5.92
CHEMBL41177 SQUAMOCIN IC50 = 1200.0 nM 5.92
CHEMBL44657 ETOPOSIDE IC50 = 1800.0 nM 5.75
CHEMBL5426008 IC50 = 1800.0 nM 5.75
CHEMBL5399730 IC50 = 2700.0 nM 5.57
CHEMBL62800 ISODESAACETYLUVARICIN IC50 = 2800.0 nM 5.55
CHEMBL1933125 UVARIGRANDIN A IC50 = 5500.0 nM 5.26
CHEMBL5410230 IC50 = 9200.0 nM 5.04
CHEMBL5405302 IC50 = 10000.0 nM 5.00
CHEMBL5431384 IC50 = 15000.0 nM 4.82
CHEMBL145449 BULLANIN IC50 = 29100.0 nM 4.54