Assay Detail
Binding
CHEMBL5359835
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NLRP3 inflammasome activation in mouse J774.A1 cells assessed as reduction in LPS-stimulated IL-1beta level pretreated for 1 hr followed by nigericin treatment for 1 hr by ELISA
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | J774.A1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NACHT, LRR and PYD domains-containing protein 3 (CHEMBL3779755) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Discovery of a dual-acting inhibitor of interleukin-1β and STATs for the treatment of inflammatory bowel disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.45 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5414924 | — | — | 1 | 6.89 |
| CHEMBL5429161 | — | — | 1 | 5.97 |
| CHEMBL5401581 | — | — | 1 | 5.96 |
| CHEMBL5424691 | — | — | 1 | 5.80 |
| CHEMBL5407779 | — | — | 1 | 5.52 |
| CHEMBL5404529 | — | — | 1 | 5.52 |
| CHEMBL5398679 | — | — | 1 | 5.47 |
| CHEMBL4846605 | — | — | 1 | 5.43 |
| CHEMBL5411280 | — | — | 1 | 5.42 |
| CHEMBL5431684 | — | — | 1 | 5.40 |
| CHEMBL5407010 | — | — | 1 | 5.31 |
| CHEMBL5435953 | — | — | 1 | 5.28 |
| CHEMBL5419637 | — | — | 1 | 5.22 |
| CHEMBL5395385 | — | — | 1 | 5.22 |
| CHEMBL5414723 | — | — | 1 | 5.22 |
| CHEMBL5411854 | — | — | 1 | 5.08 |
| CHEMBL5426512 | — | — | 1 | 4.84 |
| CHEMBL5439313 | — | — | 1 | 4.57 |
| CHEMBL5403247 | — | — | 1 | - |
| CHEMBL5420505 | — | — | 1 | - |
| CHEMBL5435228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5414924 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL5429161 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL5401581 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL5424691 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL5407779 | — | IC50 | = | 3010.0 | nM | 5.52 |
| CHEMBL5404529 | — | IC50 | = | 3020.0 | nM | 5.52 |
| CHEMBL5398679 | — | IC50 | = | 3370.0 | nM | 5.47 |
| CHEMBL4846605 | — | IC50 | = | 3670.0 | nM | 5.43 |
| CHEMBL5411280 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL5431684 | — | IC50 | = | 3960.0 | nM | 5.40 |
| CHEMBL5407010 | — | IC50 | = | 4930.0 | nM | 5.31 |
| CHEMBL5435953 | — | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL5419637 | — | IC50 | = | 5970.0 | nM | 5.22 |
| CHEMBL5395385 | — | IC50 | = | 5970.0 | nM | 5.22 |
| CHEMBL5414723 | — | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL5411854 | — | IC50 | = | 8360.0 | nM | 5.08 |
| CHEMBL5426512 | — | IC50 | = | 14400.0 | nM | 4.84 |
| CHEMBL5439313 | — | IC50 | = | 27100.0 | nM | 4.57 |
| CHEMBL5403247 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5420505 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5435228 | — | IC50 | > | 50000.0 | nM | - |