Assay Detail
Functional
CHEMBL5359989
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Antibacterial activity against Salmonella typhimurium ATCC14028 infected in mouse RAW264.7 cells assessed as reduction in intracellular bacterial growth incubated for 24 hrs in presence of gentamicin by CMFDA and DAPI staining based high-content screening method
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Salmonella typhimurium (CHEMBL351) ↗| Type | ORGANISM |
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium |
Publication
Discovery of new dibenzodiazepine derivatives as antibacterials against intracellular bacteria.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.64 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | 4.0 | 1 | 7.22 |
| CHEMBL5171589 | — | — | 1 | 6.52 |
| CHEMBL5408093 | — | — | 1 | 6.40 |
| CHEMBL5406508 | — | — | 1 | 5.94 |
| CHEMBL5394820 | — | — | 1 | 5.83 |
| CHEMBL5408960 | — | — | 1 | 5.63 |
| CHEMBL5402935 | — | — | 1 | 5.43 |
| CHEMBL5404679 | — | — | 1 | 5.38 |
| CHEMBL5431950 | — | — | 1 | 5.37 |
| CHEMBL715 | OLANZAPINE | 4.0 | 1 | 5.27 |
| CHEMBL357391 | — | — | 1 | 5.25 |
| CHEMBL831 | LOXAPINE | 4.0 | 1 | 5.24 |
| CHEMBL5437365 | — | — | 1 | 5.21 |
| CHEMBL5419106 | — | — | 1 | 5.05 |
| CHEMBL5410233 | — | — | 1 | 4.82 |
| CHEMBL5415657 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8 | CIPROFLOXACIN | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5171589 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5408093 | — | EC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5406508 | — | EC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL5394820 | — | EC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL5408960 | — | EC50 | = | 2360.0 | nM | 5.63 |
| CHEMBL5402935 | — | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5404679 | — | EC50 | = | 4170.0 | nM | 5.38 |
| CHEMBL5431950 | — | EC50 | = | 4240.0 | nM | 5.37 |
| CHEMBL715 | OLANZAPINE | EC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL357391 | — | EC50 | = | 5670.0 | nM | 5.25 |
| CHEMBL831 | LOXAPINE | EC50 | = | 5770.0 | nM | 5.24 |
| CHEMBL5437365 | — | EC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL5419106 | — | EC50 | = | 8820.0 | nM | 5.05 |
| CHEMBL5410233 | — | EC50 | = | 15150.0 | nM | 4.82 |
| CHEMBL5415657 | — | EC50 | > | 30000.0 | nM | - |