Assay Detail
Binding
CHEMBL5360424
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Agonist activity at mouse TLR7
27
Total Activities
27
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 6.74 | 7.57 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5419663 | — | — | 1 | 7.57 |
| CHEMBL5435264 | — | — | 1 | 7.57 |
| CHEMBL5404211 | — | — | 1 | 7.54 |
| CHEMBL5426019 | — | — | 1 | 7.39 |
| CHEMBL5407698 | — | — | 1 | 7.32 |
| CHEMBL5417891 | — | — | 1 | 7.13 |
| CHEMBL5427289 | — | — | 1 | 7.12 |
| CHEMBL5413224 | — | — | 1 | 6.92 |
| CHEMBL5418809 | — | — | 1 | 6.91 |
| CHEMBL5414529 | — | — | 1 | 6.90 |
| CHEMBL5434082 | — | — | 1 | 6.83 |
| CHEMBL5411647 | — | — | 1 | 6.80 |
| CHEMBL5417342 | — | — | 1 | 6.75 |
| CHEMBL5427884 | — | — | 1 | 6.33 |
| CHEMBL5419694 | — | — | 1 | 6.29 |
| CHEMBL5427789 | — | — | 1 | 6.20 |
| CHEMBL5398842 | — | — | 1 | 6.01 |
| CHEMBL5413300 | — | — | 1 | 5.79 |
| CHEMBL5427987 | — | — | 1 | 5.72 |
| CHEMBL5420635 | — | — | 1 | 5.71 |
| CHEMBL5403684 | — | — | 1 | - |
| CHEMBL5400486 | — | — | 1 | - |
| CHEMBL5427518 | — | — | 1 | - |
| CHEMBL5430110 | — | — | 1 | - |
| CHEMBL5419165 | — | — | 1 | - |
| CHEMBL5414156 | — | — | 1 | - |
| CHEMBL5424102 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5419663 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5435264 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5404211 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL5426019 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL5407698 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL5417891 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL5427289 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL5413224 | — | EC50 | = | 121.0 | nM | 6.92 |
| CHEMBL5418809 | — | EC50 | = | 124.0 | nM | 6.91 |
| CHEMBL5414529 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL5434082 | — | EC50 | = | 148.0 | nM | 6.83 |
| CHEMBL5411647 | — | EC50 | = | 159.0 | nM | 6.80 |
| CHEMBL5417342 | — | EC50 | = | 177.0 | nM | 6.75 |
| CHEMBL5427884 | — | EC50 | = | 465.0 | nM | 6.33 |
| CHEMBL5419694 | — | EC50 | = | 512.0 | nM | 6.29 |
| CHEMBL5427789 | — | EC50 | = | 626.0 | nM | 6.20 |
| CHEMBL5398842 | — | EC50 | = | 984.0 | nM | 6.01 |
| CHEMBL5413300 | — | EC50 | = | 1603.0 | nM | 5.79 |
| CHEMBL5427987 | — | EC50 | = | 1909.0 | nM | 5.72 |
| CHEMBL5420635 | — | EC50 | = | 1954.0 | nM | 5.71 |
| CHEMBL5403684 | — | Activity | - | — | - | |
| CHEMBL5400486 | — | Activity | - | — | - | |
| CHEMBL5427518 | — | Activity | - | — | - | |
| CHEMBL5430110 | — | Activity | - | — | - | |
| CHEMBL5419165 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5414156 | — | EC50 | > | 5000.0 | nM | - |
| CHEMBL5424102 | — | EC50 | > | 5000.0 | nM | - |