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Assay Detail

CHEMBL5360439

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of CYP2C19 (unknown origin)
26
Total Activities
26
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cytochrome P450 2C19 (CHEMBL3622)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification and Optimization of Small Molecule Pyrazolopyrimidine TLR7 Agonists for Applications in Immuno-oncology.
He L, Zhang MY, Cox M, Zhang Q, Donnell AF, Zhang Y, Tarby C, Gill P, Subbaiah MAM, Ramar T, Reddy M, Puttapaka V, Li YX, Sivaprakasam P, Critton D, Mulligan D, Xie C, Ramakrishnan R, Nagar J, Dudhgaonkar S, Murtaza A, Oderinde MS, Schieven GL, Mathur A, Gavai AV, Vite G, Gangwar S, Poudel YB.
ACS Med Chem Lett (2024) 15 : 189 -196
PubMed 38352849 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 5.03 5.03
Inhibition 2 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5417891 1 5.03
CHEMBL5427518 1 -
CHEMBL5420635 1 -
CHEMBL5398842 1 -
CHEMBL5427884 1 -
CHEMBL5424102 1 -
CHEMBL5414156 1 -
CHEMBL5419165 1 -
CHEMBL5419694 1 -
CHEMBL5427289 1 -
CHEMBL5426019 1 -
CHEMBL5430110 1 -
CHEMBL5418809 1 -
CHEMBL5413224 1 -
CHEMBL5400486 1 -
CHEMBL5403684 1 -
CHEMBL5413300 1 -
CHEMBL5427987 1 -
CHEMBL5417342 1 -
CHEMBL5434082 1 -
CHEMBL5414529 1 -
CHEMBL5404211 1 -
CHEMBL5427789 1 -
CHEMBL5411647 1 -
CHEMBL5407698 1 -
CHEMBL5435264 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5417891 IC50 = 9420.0 nM 5.03
CHEMBL5427518 IC50 > 20000.0 nM -
CHEMBL5420635 IC50 > 20000.0 nM -
CHEMBL5398842 IC50 > 20000.0 nM -
CHEMBL5427884 Inhibition - % -
CHEMBL5424102 IC50 > 20000.0 nM -
CHEMBL5414156 IC50 > 20000.0 nM -
CHEMBL5419165 IC50 > 20000.0 nM -
CHEMBL5419694 IC50 > 20000.0 nM -
CHEMBL5427289 IC50 > 20000.0 nM -
CHEMBL5426019 IC50 > 20000.0 nM -
CHEMBL5430110 IC50 > 20000.0 nM -
CHEMBL5418809 IC50 > 20000.0 nM -
CHEMBL5413224 IC50 > 20000.0 nM -
CHEMBL5400486 IC50 > 20000.0 nM -
CHEMBL5403684 IC50 > 20000.0 nM -
CHEMBL5413300 IC50 > 17000.0 nM -
CHEMBL5427987 IC50 > 20000.0 nM -
CHEMBL5417342 IC50 > 14000.0 nM -
CHEMBL5434082 IC50 > 20000.0 nM -
CHEMBL5414529 IC50 > 20000.0 nM -
CHEMBL5404211 IC50 > 20000.0 nM -
CHEMBL5427789 Inhibition - % -
CHEMBL5411647 IC50 > 20000.0 nM -
CHEMBL5407698 IC50 > 20000.0 nM -
CHEMBL5435264 IC50 > 20000.0 nM -