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Assay Detail

CHEMBL5360715

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of mouse nNOS
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Nitric oxide synthase 1 (CHEMBL4719)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Chemical similarities and differences among inhibitors of nitric oxide synthase, arginase and dimethylarginine dimethylaminohydrolase-1: Implications for the design of novel enzyme inhibitors modulating the nitric oxide pathway.
Doman AJ, Tommasi S, Perkins MV, McKinnon RA, Mangoni AA, Nair PC.
Bioorg Med Chem (2022) 72 : 116970 -116970
PubMed 36063653 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.52 5.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL11471 L-NIO 1 5.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL11471 L-NIO IC50 = 3000.0 nM 5.52