Assay Detail
Binding
CHEMBL5360719
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human nNOS
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical similarities and differences among inhibitors of nitric oxide synthase, arginase and dimethylarginine dimethylaminohydrolase-1: Implications for the design of novel enzyme inhibitors modulating the nitric oxide pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.98 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106871 | — | — | 1 | 9.00 |
| CHEMBL1221704 | — | — | 1 | 6.00 |
| CHEMBL420671 | — | — | 1 | 4.70 |
| CHEMBL7889 | L-NIL | — | 1 | 4.21 |
| CHEMBL5422496 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106871 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1221704 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL420671 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL7889 | L-NIL | IC50 | = | 61000.0 | nM | 4.21 |
| CHEMBL5422496 | — | IC50 | = | 150000.0 | nM | - |