Assay Detail
Binding
CHEMBL5360776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DDAH1 expressed in Escherichia coli BL21 cells measured after 30 mins by calorimetric assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (CHEMBL6036) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Chemical similarities and differences among inhibitors of nitric oxide synthase, arginase and dimethylarginine dimethylaminohydrolase-1: Implications for the design of novel enzyme inhibitors modulating the nitric oxide pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.36 | 4.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106820 | — | — | 1 | 4.92 |
| CHEMBL197234 | — | — | 1 | 4.26 |
| CHEMBL442896 | — | — | 1 | 4.16 |
| CHEMBL456882 | — | — | 1 | 4.10 |
| CHEMBL107528 | — | — | 1 | - |
| CHEMBL106425 | 5-N-ALLYL-ARGININE | — | 1 | - |
| CHEMBL106423 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106820 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL197234 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL442896 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL456882 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL107528 | — | IC50 | = | 283000.0 | nM | - |
| CHEMBL106425 | 5-N-ALLYL-ARGININE | IC50 | = | 207000.0 | nM | - |
| CHEMBL106423 | — | IC50 | = | 189000.0 | nM | - |