Assay Detail
Binding
CHEMBL5360778
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human DDAH1 expressed in HEK293 cells using ADMA as substrate preincubated for 5 mins
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (CHEMBL6036) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Chemical similarities and differences among inhibitors of nitric oxide synthase, arginase and dimethylarginine dimethylaminohydrolase-1: Implications for the design of novel enzyme inhibitors modulating the nitric oxide pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.91 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4444007 | — | — | 1 | 5.52 |
| CHEMBL5437726 | — | — | 1 | 4.75 |
| CHEMBL5410984 | — | — | 1 | 4.47 |
| CHEMBL5438148 | — | — | 1 | - |
| CHEMBL5434286 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4444007 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5437726 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5410984 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL5438148 | — | IC50 | = | 230000.0 | nM | - |
| CHEMBL5434286 | — | IC50 | = | 131000.0 | nM | - |