Assay Detail
Binding
CHEMBL5360792
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Inhibition of human nNOS assessed as inhibition constant measured after 5 mins
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chemical similarities and differences among inhibitors of nitric oxide synthase, arginase and dimethylarginine dimethylaminohydrolase-1: Implications for the design of novel enzyme inhibitors modulating the nitric oxide pathway.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.11 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL106820 | — | — | 1 | 7.05 |
| CHEMBL11471 | L-NIO | — | 1 | 5.77 |
| CHEMBL5440688 | — | — | 1 | 5.52 |
| CHEMBL595227 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL106820 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL11471 | L-NIO | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL5440688 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL595227 | — | Ki | > | 1900000.0 | nM | - |