Assay Detail
Functional
CHEMBL5360879
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Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell viability incubated for 48 hrs by CCK8 method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Ligand- and structure-based identification of novel CDK9 inhibitors for the potential treatment of leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.27 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.52 |
| CHEMBL5413586 | — | — | 1 | 5.49 |
| CHEMBL5434101 | — | — | 1 | 4.81 |
| CHEMBL5404071 | — | — | 1 | 4.65 |
| CHEMBL1387710 | — | — | 1 | 4.58 |
| CHEMBL1568996 | — | — | 1 | 4.57 |
| CHEMBL5425180 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL5413586 | — | IC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL5434101 | — | IC50 | = | 15630.0 | nM | 4.81 |
| CHEMBL5404071 | — | IC50 | = | 22220.0 | nM | 4.65 |
| CHEMBL1387710 | — | IC50 | = | 26630.0 | nM | 4.58 |
| CHEMBL1568996 | — | IC50 | = | 27210.0 | nM | 4.57 |
| CHEMBL5425180 | — | IC50 | > | 50000.0 | nM | - |