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Assay Detail

CHEMBL5361047

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anticancer activity against human HCT-116 cells assessed as cell growth inhibition measured after 48 hrs by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Structure activity relationship (SAR) and anticancer activity of pyrrolidine derivatives: Recent developments and future prospects (A review).
Bhat AA, Singh I, Tandon N, Tandon R.
Eur J Med Chem (2023) 246 : 114954 -114954
PubMed 36481599 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 22 5.73 5.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5400688 1 5.80
CHEMBL5403383 1 5.80
CHEMBL5424905 1 5.80
CHEMBL5416179 1 5.80
CHEMBL5397468 1 5.80
CHEMBL5420648 1 5.80
CHEMBL5416508 1 5.80
CHEMBL5407442 1 5.80
CHEMBL5401285 1 5.80
CHEMBL5426488 1 5.80
CHEMBL1275863 1 5.76
CHEMBL5416831 1 5.70
CHEMBL5394930 1 5.66
CHEMBL5432088 1 5.60
CHEMBL5422490 1 5.60
CHEMBL5402488 1 5.55
CHEMBL5434574 1 5.52
CHEMBL5418884 1 -
CHEMBL5437781 1 -
CHEMBL5402220 1 -
CHEMBL5397602 1 -
CHEMBL5439453 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5400688 IC50 = 1570.0 nM 5.80
CHEMBL5403383 IC50 = 1570.0 nM 5.80
CHEMBL5424905 IC50 = 1570.0 nM 5.80
CHEMBL5416179 IC50 = 1570.0 nM 5.80
CHEMBL5397468 IC50 = 1570.0 nM 5.80
CHEMBL5420648 IC50 = 1570.0 nM 5.80
CHEMBL5416508 IC50 = 1570.0 nM 5.80
CHEMBL5407442 IC50 = 1570.0 nM 5.80
CHEMBL5401285 IC50 = 1570.0 nM 5.80
CHEMBL5426488 IC50 = 1570.0 nM 5.80
CHEMBL1275863 IC50 = 1740.0 nM 5.76
CHEMBL5416831 IC50 = 2000.0 nM 5.70
CHEMBL5394930 IC50 = 2200.0 nM 5.66
CHEMBL5432088 IC50 = 2500.0 nM 5.60
CHEMBL5422490 IC50 = 2500.0 nM 5.60
CHEMBL5402488 IC50 = 2800.0 nM 5.55
CHEMBL5434574 IC50 = 3000.0 nM 5.52
CHEMBL5418884 IC50 < 3000.0 nM -
CHEMBL5437781 IC50 < 3000.0 nM -
CHEMBL5402220 IC50 = 1.57 ug.mL-1 -
CHEMBL5397602 IC50 = 1.57 ug.mL-1 -
CHEMBL5439453 IC50 = 1.57 ug.mL-1 -