Assay Detail
Binding
CHEMBL5361128
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Inhibition of human SIRT5
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
NAD-dependent protein deacylase sirtuin-5, mitochondrial (CHEMBL2163183) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Pyrazolone derivatives as potent and selective small-molecule SIRT5 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.74 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4636862 | — | — | 1 | 6.96 |
| CHEMBL5182606 | — | — | 1 | 6.47 |
| CHEMBL5199472 | — | — | 1 | 5.66 |
| CHEMBL5187910 | — | — | 1 | 5.60 |
| CHEMBL4875043 | — | — | 1 | 5.52 |
| CHEMBL1201346 | BALSALAZIDE | 4.0 | 1 | 5.28 |
| CHEMBL4072635 | — | — | 1 | 5.25 |
| CHEMBL5204662 | — | — | 1 | 5.14 |
| CHEMBL5199270 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4636862 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5182606 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5199472 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL5187910 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4875043 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1201346 | BALSALAZIDE | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL4072635 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL5204662 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL5199270 | — | IC50 | <= | 50.0 | nM | - |