Assay Detail
Binding
CHEMBL5361429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Saccharomyces cerevisiae alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate preincubated for 15 mins followed by substrate addition and measured after 30 mins by spectrophotometric analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Alpha-glucosidase (CHEMBL5291954) ↗| Type | PROTEIN FAMILY |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Synthetic α-glucosidase inhibitors as promising anti-diabetic agents: Recent developments and future challenges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.11 | 5.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4516073 | — | — | 1 | 5.59 |
| CHEMBL4453256 | — | — | 1 | 5.54 |
| CHEMBL4436320 | — | — | 1 | 5.22 |
| CHEMBL5419232 | — | — | 1 | 4.89 |
| CHEMBL4539474 | — | — | 1 | 4.71 |
| CHEMBL5394927 | — | — | 1 | 4.68 |
| CHEMBL404271 | ACARBOSE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4516073 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL4453256 | — | IC50 | = | 2850.0 | nM | 5.54 |
| CHEMBL4436320 | — | IC50 | = | 5980.0 | nM | 5.22 |
| CHEMBL5419232 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL4539474 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL5394927 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL404271 | ACARBOSE | IC50 | = | 817380.0 | nM | - |