Assay Detail
Binding
CHEMBL5361632
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant rat P2X7 receptor by FLIPR assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From lead to clinic: A review of the structural design of P2X7R antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.22 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3697516 | — | — | 1 | 8.60 |
| CHEMBL3697521 | — | — | 1 | 8.36 |
| CHEMBL3697509 | — | — | 1 | 8.35 |
| CHEMBL3697511 | — | — | 1 | 8.09 |
| CHEMBL3697517 | — | — | 1 | 6.74 |
| CHEMBL3697540 | — | — | 1 | 5.40 |
| CHEMBL3697551 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3697516 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3697521 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL3697509 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL3697511 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL3697517 | — | IC50 | = | 180.3 | nM | 6.74 |
| CHEMBL3697540 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL3697551 | — | IC50 | = | 10000.0 | nM | 5.00 |