Assay Detail
Binding
CHEMBL5361760
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RSK2 expressed in human MCF7 cells incubated for 1 hrs by
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
RSK inhibitors as potential anticancer agents: Discovery, optimization, and challenges.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.48 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL150 | KAEMPFEROL | 1.0 | 1 | 5.77 |
| CHEMBL151 | LUTEOLIN | 2.0 | 1 | 5.36 |
| CHEMBL8996 | ERIODICTYOL | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL150 | KAEMPFEROL | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL151 | LUTEOLIN | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL8996 | ERIODICTYOL | IC50 | = | 4770.0 | nM | 5.32 |