Assay Detail
Functional
CHEMBL5361965
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV-1 clinical isolate 97 TH-NP1525 infected in human CEMx174 5.25M7 cells assessed as reduction in p24 antigen level measured after 4 days by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Multitargeted drug design strategy for discovery of short-peptide-based HIV-1 entry inhibitors with high potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 8.88 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5414303 | — | — | 1 | 9.48 |
| CHEMBL5410204 | — | — | 1 | 9.00 |
| CHEMBL525076 | ENFUVIRTIDE | 4.0 | 1 | 8.60 |
| CHEMBL5415654 | — | — | 1 | 8.43 |
| CHEMBL207004 | — | — | 1 | - |
| CHEMBL5438380 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5414303 | — | EC50 | = | 0.33 | nM | 9.48 |
| CHEMBL5410204 | — | EC50 | = | 0.99 | nM | 9.00 |
| CHEMBL525076 | ENFUVIRTIDE | EC50 | = | 2.54 | nM | 8.60 |
| CHEMBL5415654 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL207004 | — | EC50 | > | 300.0 | nM | - |
| CHEMBL5438380 | — | EC50 | > | 300.0 | nM | - |