Assay Detail
Toxicity
CHEMBL5362140
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Cytotoxicity against human BEAS-2B cells incubated for 72 hrs by CCK-8 assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Homo sapiens |
| Cell Type | BEAS-2B |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based discovery of novel α-aminoketone derivatives as dual p53-MDM2/MDMX inhibitors for the treatment of cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.77 | 4.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5426939 | — | — | 1 | 4.79 |
| CHEMBL5418298 | — | — | 1 | 4.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5426939 | — | IC50 | = | 16310.0 | nM | 4.79 |
| CHEMBL5418298 | — | IC50 | = | 17960.0 | nM | 4.75 |