Assay Detail
Binding
CHEMBL5362754
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Inhibition of recombinant Pseudomonas aeruginosa LpxC expressed in Escherichia coli
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pseudomonas aeruginosa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
UDP-3-O-acyl-N-acetylglucosamine deacetylase (CHEMBL2163170) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa |
Publication
Small molecule LpxC inhibitors against gram-negative bacteria: Advances and future perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 8.63 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4215934 | — | — | 1 | 9.21 |
| CHEMBL3939284 | ACHN-975 | 1.0 | 1 | 9.17 |
| CHEMBL5396682 | — | — | 1 | 9.15 |
| CHEMBL5400660 | — | — | 1 | 7.92 |
| CHEMBL5394770 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4215934 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL3939284 | ACHN-975 | IC50 | = | 0.68 | nM | 9.17 |
| CHEMBL5396682 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL5400660 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL5394770 | — | IC50 | = | 19.0 | nM | 7.72 |