Assay Detail
Binding
CHEMBL5362932
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Inhibition of human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition by DTNB based Ellman's method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and anti-Alzheimer potential of novel α-amino phosphonate derivatives and probing their molecular interaction mechanism with acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.54 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 6.23 |
| CHEMBL5433354 | — | — | 1 | 5.94 |
| CHEMBL5421943 | — | — | 1 | 5.75 |
| CHEMBL5402496 | — | — | 1 | 5.59 |
| CHEMBL5429003 | — | — | 1 | 5.58 |
| CHEMBL5407606 | — | — | 1 | 5.53 |
| CHEMBL5407691 | — | — | 1 | 5.52 |
| CHEMBL5424712 | — | — | 1 | 5.47 |
| CHEMBL5426913 | — | — | 1 | 5.36 |
| CHEMBL5424767 | — | — | 1 | 5.31 |
| CHEMBL5433166 | — | — | 1 | 5.27 |
| CHEMBL5412970 | — | — | 1 | 5.25 |
| CHEMBL5420040 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL659 | GALANTAMINE | IC50 | = | 594.0 | nM | 6.23 |
| CHEMBL5433354 | — | IC50 | = | 1157.0 | nM | 5.94 |
| CHEMBL5421943 | — | IC50 | = | 1782.0 | nM | 5.75 |
| CHEMBL5402496 | — | IC50 | = | 2554.0 | nM | 5.59 |
| CHEMBL5429003 | — | IC50 | = | 2653.0 | nM | 5.58 |
| CHEMBL5407606 | — | IC50 | = | 2943.0 | nM | 5.53 |
| CHEMBL5407691 | — | IC50 | = | 3016.0 | nM | 5.52 |
| CHEMBL5424712 | — | IC50 | = | 3365.0 | nM | 5.47 |
| CHEMBL5426913 | — | IC50 | = | 4344.0 | nM | 5.36 |
| CHEMBL5424767 | — | IC50 | = | 4927.0 | nM | 5.31 |
| CHEMBL5433166 | — | IC50 | = | 5353.0 | nM | 5.27 |
| CHEMBL5412970 | — | IC50 | = | 5623.0 | nM | 5.25 |
| CHEMBL5420040 | — | IC50 | = | 6052.0 | nM | 5.22 |