Assay Detail
Functional
CHEMBL5363296
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 cells assessed as inhibition of viral replication incubated for 24 hrs by IFA assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero C1008 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Synthesis, cytotoxicity, and pharmacokinetic evaluations of niclosamide analogs for anti-SARS-CoV-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.77 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5408364 | — | — | 1 | 6.00 |
| CHEMBL5412883 | — | — | 1 | 6.00 |
| CHEMBL2088014 | — | — | 1 | 5.88 |
| CHEMBL2313109 | — | — | 1 | 5.79 |
| CHEMBL5418982 | — | — | 1 | 5.79 |
| CHEMBL5422612 | — | — | 1 | 5.57 |
| CHEMBL1448 | NICLOSAMIDE | 4.0 | 1 | 5.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5408364 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5412883 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2088014 | — | EC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL2313109 | — | EC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL5418982 | — | EC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL5422612 | — | EC50 | = | 2670.0 | nM | 5.57 |
| CHEMBL1448 | NICLOSAMIDE | EC50 | = | 4630.0 | nM | 5.33 |