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Compound Detail

CHEMBL5408364

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O=C(Nc1ccc(C(F)(F)F)cc1)c1cc(Cl)c(F)cc1O

Basic Information

ChEMBL ID CHEMBL5408364
Phase Preclinical
Structure Type MOL
InChI Key GNWZUDGPCIDWAA-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
5
PK Parameters
3
Publications
0
Known Names

Molecular Properties

333.7
MW (Da)
4.46
ALogP
2
HBA
2
HBD
49.3
PSA (Ų)
0.80
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H8ClF4NO2
MW 333.67
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -1.67

Activity Summary

EC50 1 meas. best 6.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
SARS-CoV-2
CHEMBL4303835
EC50 6.0 6.0 1000.0 1

Pharmacokinetic Data

Parameter Value Units Species
AUC 1563.0 ng.hr.mL-1 Mus musculus
AUC 1573.0 ng.hr.mL-1 Mus musculus
Cmax 1354.63 nM Mus musculus
MRT 5.45 hr Mus musculus
T1/2 3.1 hr Mus musculus

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
SARS-CoV-2 EC50 = 1000.0 nM 6.0 Antiviral activity against SARS-CoV-2 infected in African green monkey Vero E6 c... 37058956

Literature References

PubMed DOI Target Context # Activities
37058956 10.1016/j.ejmech.2023.115320 ADMET 6
37058956 10.1016/j.ejmech.2023.115320 SARS-CoV-2 2
37058956 10.1016/j.ejmech.2023.115320 Vero C1008 1

Data from ChEMBL 36 via Core Engine