Assay Detail
Functional
CHEMBL5363607
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability incubated for 48 hrs by celltiter glo-luminescent assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.76 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5441034 | — | — | 1 | 6.47 |
| CHEMBL5399073 | — | — | 1 | 6.14 |
| CHEMBL5416704 | — | — | 1 | 6.07 |
| CHEMBL5402777 | — | — | 1 | 5.87 |
| CHEMBL5407869 | — | — | 1 | 5.86 |
| CHEMBL5426088 | — | — | 1 | 5.68 |
| CHEMBL5409286 | — | — | 1 | 5.62 |
| CHEMBL5414510 | — | — | 1 | 5.55 |
| CHEMBL5419713 | — | — | 1 | 5.50 |
| CHEMBL5426808 | — | — | 1 | 5.33 |
| CHEMBL5397160 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5441034 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL5399073 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5416704 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5402777 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL5407869 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL5426088 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL5409286 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL5414510 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL5419713 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5426808 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5397160 | — | IC50 | = | 4740.0 | nM | 5.32 |