Assay Detail
Functional
CHEMBL5363679
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Antiproliferative activity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Glo assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MOLM-13 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel Dihydroorotate Dehydrogenase Inhibitors for Treating Acute Myelogenous Leukemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 10.02 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5437916 | — | — | 1 | 10.52 |
| CHEMBL5411333 | — | — | 1 | 10.15 |
| CHEMBL5419305 | — | — | 1 | 10.10 |
| CHEMBL5431927 | — | — | 1 | 10.05 |
| CHEMBL5439317 | — | — | 1 | 9.68 |
| CHEMBL5428953 | — | — | 1 | 9.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5437916 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL5411333 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL5419305 | — | IC50 | = | 0.08 | nM | 10.10 |
| CHEMBL5431927 | — | IC50 | = | 0.09 | nM | 10.05 |
| CHEMBL5439317 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL5428953 | — | IC50 | = | 0.26 | nM | 9.59 |