Assay Detail
Binding
CHEMBL5363712
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Nav 1.4 expressed in HEK293T cells assessed as phasic block at 10 Hz by whole cell patch clamp assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293T |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium channel protein type 4 subunit alpha (CHEMBL2072) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Riluzole Analogs with Improved Use-Dependent Inhibition of Skeletal Muscle Sodium Channels.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 4.25 | 4.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5394673 | — | — | 1 | 4.42 |
| CHEMBL744 | RILUZOLE | 4.0 | 1 | 4.29 |
| CHEMBL442384 | — | — | 1 | 4.28 |
| CHEMBL5434746 | — | — | 1 | 4.20 |
| CHEMBL97407 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5394673 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL744 | RILUZOLE | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL442384 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL5434746 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL97407 | — | IC50 | = | 89000.0 | nM | 4.05 |