Assay Detail
Binding
CHEMBL5363952
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human CK1 epsilon using casein and [gamma33P]ATP as substrate incubated for 60 mins by radiometric 33PanQinase assay
228
Total Activities
228
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Leucettinibs, a Class of DYRK/CLK Kinase Inhibitors Inspired by the Marine Sponge Natural Product Leucettamine B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 228 | 5.62 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5422486 | — | — | 1 | 7.21 |
| CHEMBL5396550 | — | — | 1 | 6.38 |
| CHEMBL5438158 | — | — | 1 | 6.21 |
| CHEMBL5405059 | — | — | 1 | 5.96 |
| CHEMBL5422654 | — | — | 1 | 5.92 |
| CHEMBL5412565 | — | — | 1 | 5.83 |
| CHEMBL5417147 | — | — | 1 | 5.75 |
| CHEMBL5438728 | — | — | 1 | 5.71 |
| CHEMBL5418722 | — | — | 1 | 5.64 |
| CHEMBL5400230 | — | — | 1 | 5.61 |
| CHEMBL5406081 | — | — | 1 | 5.56 |
| CHEMBL5397343 | — | — | 1 | 5.46 |
| CHEMBL5441121 | — | — | 1 | 5.39 |
| CHEMBL5404544 | — | — | 1 | 5.33 |
| CHEMBL5421442 | — | — | 1 | 5.30 |
| CHEMBL5409574 | — | — | 1 | 5.24 |
| CHEMBL5439276 | — | — | 1 | 5.20 |
| CHEMBL5436133 | — | — | 1 | 5.16 |
| CHEMBL5411888 | — | — | 1 | 5.07 |
| CHEMBL5430357 | — | — | 1 | 5.01 |
| CHEMBL5428651 | — | — | 1 | 5.01 |
| CHEMBL5395680 | — | — | 1 | - |
| CHEMBL5414361 | — | — | 1 | - |
| CHEMBL5410738 | — | — | 1 | - |
| CHEMBL5435718 | — | — | 1 | - |
| CHEMBL5394477 | — | — | 1 | - |
| CHEMBL5419006 | — | — | 1 | - |
| CHEMBL5437222 | — | — | 1 | - |
| CHEMBL5394278 | — | — | 1 | - |
| CHEMBL5412478 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5422486 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL5396550 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL5438158 | — | IC50 | = | 612.0 | nM | 6.21 |
| CHEMBL5405059 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5422654 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5412565 | — | IC50 | = | 1476.0 | nM | 5.83 |
| CHEMBL5417147 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL5438728 | — | IC50 | = | 1948.0 | nM | 5.71 |
| CHEMBL5418722 | — | IC50 | = | 2267.0 | nM | 5.64 |
| CHEMBL5400230 | — | IC50 | = | 2434.0 | nM | 5.61 |
| CHEMBL5406081 | — | IC50 | = | 2746.0 | nM | 5.56 |
| CHEMBL5397343 | — | IC50 | = | 3427.0 | nM | 5.46 |
| CHEMBL5441121 | — | IC50 | = | 4048.0 | nM | 5.39 |
| CHEMBL5404544 | — | IC50 | = | 4694.0 | nM | 5.33 |
| CHEMBL5421442 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL5409574 | — | IC50 | = | 5807.0 | nM | 5.24 |
| CHEMBL5439276 | — | IC50 | = | 6345.0 | nM | 5.20 |
| CHEMBL5436133 | — | IC50 | = | 6926.0 | nM | 5.16 |
| CHEMBL5411888 | — | IC50 | = | 8460.0 | nM | 5.07 |
| CHEMBL5430357 | — | IC50 | = | 9752.0 | nM | 5.01 |
| CHEMBL5428651 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL5406461 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5411626 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5401217 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5439392 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5414635 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5413503 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5430988 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5431414 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5430415 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5423063 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5417890 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5412101 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5435495 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5398161 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5424074 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5421200 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5416947 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5434955 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5404644 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5422100 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5438412 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5426735 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5428794 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5438852 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5406568 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5428107 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5395707 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5405680 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5399810 | — | IC50 | > | 10000.0 | nM | - |