Assay Detail
Binding
CHEMBL5364235
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Inhibition of NNMT in human 769-P cells assessed as MNA level incubated for 48 hrs by MRM analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | 769-P |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship Studies on Cell-Potent Nicotinamide <i>N</i>-Methyltransferase Bisubstrate Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.65 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5408922 | — | — | 1 | 7.00 |
| CHEMBL5433732 | — | — | 1 | 7.00 |
| CHEMBL5407922 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5408922 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5433732 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5407922 | — | IC50 | = | 1100.0 | nM | 5.96 |