Assay Detail
Binding
CHEMBL5364262
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal his6-tagged human recombinant AspH (315 to 758 residues) expressed in Escherichia coli BL21 (DE3) cells by SPE-MS analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aspartyl/asparaginyl beta-hydroxylase (CHEMBL4680030) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.46 | 6.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5429223 | — | — | 1 | 6.55 |
| CHEMBL5415306 | — | — | 1 | 6.24 |
| CHEMBL5429166 | — | — | 1 | 5.91 |
| CHEMBL5423241 | — | — | 1 | 5.73 |
| CHEMBL5414235 | — | — | 1 | 5.40 |
| CHEMBL5401915 | — | — | 1 | 5.12 |
| CHEMBL5438950 | — | — | 1 | 4.97 |
| CHEMBL5414033 | — | — | 1 | 4.96 |
| CHEMBL5397863 | — | — | 1 | 4.88 |
| CHEMBL5409822 | — | — | 1 | 4.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5429223 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5415306 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL5429166 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL5423241 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL5414235 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL5401915 | — | IC50 | = | 7660.0 | nM | 5.12 |
| CHEMBL5438950 | — | IC50 | = | 10760.0 | nM | 4.97 |
| CHEMBL5414033 | — | IC50 | = | 10910.0 | nM | 4.96 |
| CHEMBL5397863 | — | IC50 | = | 13130.0 | nM | 4.88 |
| CHEMBL5409822 | — | IC50 | = | 16100.0 | nM | 4.79 |