Assay Detail
Functional
CHEMBL5364542
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinflammatory activity against LPS-stimulated human PBMC cells assessed reduction in TNFalpha level incubated for 18 hrs by ELISA analysis
10
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Optimization of M<sub>3</sub> Antagonist-PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 8.78 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5417689 | — | — | 1 | 9.50 |
| CHEMBL5409010 | — | — | 1 | 9.40 |
| CHEMBL5408238 | — | — | 2 | 9.30 |
| CHEMBL5426968 | — | — | 1 | 8.80 |
| CHEMBL5399363 | — | — | 2 | 8.80 |
| CHEMBL5410533 | — | — | 1 | 8.60 |
| CHEMBL5395712 | — | — | 2 | 7.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5417689 | — | IC50 | = | 0.3162 | nM | 9.50 |
| CHEMBL5409010 | — | IC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL5408238 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL5408238 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL5426968 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL5399363 | — | IC50 | = | 1.585 | nM | 8.80 |
| CHEMBL5410533 | — | IC50 | = | 2.512 | nM | 8.60 |
| CHEMBL5399363 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL5395712 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL5395712 | — | IC50 | = | 15.85 | nM | 7.80 |