Assay Detail
Binding
CHEMBL5364589
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Inhibition of eGFP-fused SARS-CoV-2 main protease transfected in HEK293T/17 cells incubated for 3 days by flow cytometry analysis
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | HEK293T/17 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
A Systematic Survey of Reversibly Covalent Dipeptidyl Inhibitors of the SARS-CoV-2 Main Protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.14 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5435470 | — | — | 1 | 7.07 |
| CHEMBL5399799 | — | — | 1 | 7.06 |
| CHEMBL5195325 | — | — | 1 | 6.57 |
| CHEMBL5288416 | — | — | 1 | 6.55 |
| CHEMBL5438286 | — | — | 1 | 6.37 |
| CHEMBL5425010 | — | — | 1 | 6.25 |
| CHEMBL3427141 | — | — | 1 | 6.23 |
| CHEMBL5270743 | — | — | 1 | 6.19 |
| CHEMBL4796938 | — | — | 1 | 6.18 |
| CHEMBL5398423 | — | — | 1 | 6.18 |
| CHEMBL5415290 | — | — | 1 | 6.14 |
| CHEMBL3427168 | — | — | 1 | 6.11 |
| CHEMBL5431050 | — | — | 1 | 6.04 |
| CHEMBL5276875 | — | — | 1 | 5.96 |
| CHEMBL5427537 | — | — | 1 | 5.80 |
| CHEMBL5267952 | — | — | 1 | 5.57 |
| CHEMBL5437518 | — | — | 1 | 5.54 |
| CHEMBL5396546 | — | — | 1 | 5.46 |
| CHEMBL5398911 | — | — | 1 | 5.44 |
| CHEMBL5397315 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5435470 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL5399799 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL5195325 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL5288416 | — | EC50 | = | 280.0 | nM | 6.55 |
| CHEMBL5438286 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL5425010 | — | EC50 | = | 560.0 | nM | 6.25 |
| CHEMBL3427141 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL5270743 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4796938 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5398423 | — | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL5415290 | — | EC50 | = | 730.0 | nM | 6.14 |
| CHEMBL3427168 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5431050 | — | EC50 | = | 910.0 | nM | 6.04 |
| CHEMBL5276875 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5427537 | — | EC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL5267952 | — | EC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL5437518 | — | EC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL5396546 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL5398911 | — | EC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL5397315 | — | EC50 | > | 10000.0 | nM | - |